Radiesse® As elastin and collagen production declines, aging skin loses its young texture and appearance. Dynamic lines become static wrinkles, and as tissues lose volume, the face may also lose some of its structure. Radiesse®, a relatively recent cosmetic procedure, is the radical solution to this issue. Describe Radiesse®. A dermal filler called Radiesse® has been approved for the treatment of facial wrinkles, creases, and skin folds. Particles of calcium hydroxylapatite are suspended in a gel solution in this FDA-approved product. The body naturally produces calcium hydroxylapatite, which has long been employed as a component in a variety of pharmaceutical formulations. Radiesse® is an allergen-free mixture of this component plus a gel carrier. Radiesse®: How Does It Work? The tissues underneath the area being treated with Radiesse® are injected.